Mr Sharon, 85, is suffering from a malfunction of several organs including the kidneys, they said.
He became prime minister in 2001 and suffered a mild stroke in 2005.
After a second, major stroke in 2006, he went into a coma and has been in a persistent vegetative state ever since.
Giving the first official medical statement on the current situation, Professor Zeev Rotstein of Tel Hashomer hospital, said: "I am no prophet, but the feeling of his doctors and his sons... is that there has been a change for the worse.
He became prime minister in 2001 and suffered a mild stroke in 2005.
After a second, major stroke in 2006, he went into a coma and has been in a persistent vegetative state ever since.
Giving the first official medical statement on the current situation, Professor Zeev Rotstein of Tel Hashomer hospital, said: "I am no prophet, but the feeling of his doctors and his sons... is that there has been a change for the worse.
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